The Watchman On The Wall

The Watchman On The Wall
Eph 6:12 For we wrestle not against flesh and blood, but against principalities, against powers, against the rulers of the darkness of this world, against spiritual wickedness in high places. Verse 13 Wherefore take unto you the whole armour of God, that ye may be able to withstand in the evil day, and having done all, to stand.

Tuesday, October 9, 2012

Genetically Engineered Foods Or GMO


California Prepares to Vote on Genetically Engineered Foods
Richard Dahl


Posted: 10/09/2012; Environ Health Perspect. 2012;1(9):A359-A361. © 2012 
National Institute of Environmental Health Sciences

Abstract and Introduction
Introduction
Since they were first commercially grown in the mid-1990s, genetically 
engineered (GE) crops have expanded across the globe, offering farmers the 
advantages of genetically enhanced resistance to drought, herbicides, and 
insects. According to the International Service for the Acquisition of 
Agri-Biotech Applications (ISAAA), a crop biotechnology advocacy 
organization, farmers in 29 countries grew nearly 400 million acres of 
commercial GE crops in 2011, an 8% increase from the previous year.[1] An 
estimated 60–70% of processed foods in the United States contain GE 
ingredients,[2] and GE corn and soybeans make up the majority of the U.S. 
crop.[3]

But while GE crop acreage has been steadily increasing, so have concerns in 
some quarters that producing and eating GE foods may pose unexpected 
environmental and health hazards. In the absence of strong health and safety 
data, many national governments across the world have taken steps to 
minimize the presence of GE food within their borders. In Europe, six 
nations (Austria, France, Germany, Greece, Hungary, and Luxembourg) have 
enacted bans on the cultivation and import of GE products,[4] and nearly 50 
nations worldwide require that all GE foods be labeled as such.[5]

In the United States, consumer concern about GE foods has been slower to 
surface. But that's changing—and a ballot question this fall in California 
has the potential to radically alter the GE landscape throughout the rest of 
the United States. On 6 November 2012 California voters will decide whether 
foods containing genetically modified organisms (GMOs) must be labeled.

If passed, the California Right to Know Genetically Engineered Food Act—also 
known as Proposition 37—would require that all raw food products containing 
GMOs be labeled as "genetically engineered" and that any processed foods 
containing GMOs be labeled as "partially produced with genetic engineering" 
or "may be partially produced with genetic engineering," with implementation 
due 1 July 2014.[6] The law would exempt meat, dairy, and other products 
from animals that consumed feed containing GMOs but would cover such 
products from animals that were themselves genetically engineered. It would 
also exempt food sold in restaurants and alcohol.

The initiative has touched off a heated battle in the Golden State. On one 
side, pro-labeling advocates claim the safety of GE foods is unknown and 
that consumers have the right to know what's in their food. Opposing them 
are an array of groups in mainstream agribusiness, the grocery industry, and 
the biotech industry, many of whom would bear the cost of implementing new 
labeling as well as potential loss of sales to wary consumers who aren't 
sure what the labels mean or whether they should be worried.

Kathy Fairbanks, spokeswoman for the Coalition Against the Deceptive Food 
Labeling Scheme, which represents these groups, claims the initiative would 
"force California families to pay hundreds of dollars more in higher food 
prices, would cost millions in government bureaucracy, and would not provide 
any health and safety benefits." The coalition also says the bill's many 
exemptions make no sense and will only confuse and mislead consumers, asking 
on its website, "If Prop 37 was really about the 'right to know,' why did 
proponents include so many special-interest exemptions?"[7]

But Stacy Malkan, Fairbanks' counterpart for the pro-labeling organization 
California Right to Know, says there's no evidence to support the claim that 
Californians' grocery bills would go up if the labeling measure passes. She 
also says that while there's no conclusive evidence that GE foods are 
unsafe, there also is no conclusive evidence that they are. "Many scientists 
are saying that in the face of scientific uncertainty, labeling is an 
important tool to help track potential health risks," she says.

Michael Hansen, a senior staff scientist at Consumers Union, offers a 
theoretical example of how such tracking might work: "If you take a gene 
from the kiwi fruit, put it into a tomato, and the tomato gets turned into 
sauce for your pizza, and there's an allergic reaction, only the genetically 
altered tomato would produce that allergic reaction. … This is not like 
[allergy concerns associated with] conventional foods because the problem is 
going to be for one particular [bioengineered modification]. How are you 
going to figure that out unless it's labeled? You can't. And that's why so 
many countries have labeling."

Accepted Technologies
Although campaigns for and against GE labeling in California are focusing 
heavily on economic impacts, the real debate revolves around a scientific 
question: Are these foods truly safe or not?

"I think it's fair to say that most scientists think the techniques that are 
used [to create GE plants] are not inherently dangerous," says Peggy Lemaux, 
a cooperative extension specialist in the Plant and Microbial Biology 
Department at the University of California, Berkeley. In fact, in 2010 the 
European Commission released an analysis of 50 studies conducted on GE foods 
over the last 25 years and concluded that GE technologies posed no greater 
risks than conventional breeding technologies.[8]

To create a GE crop strain, researchers first identify a gene from an 
unrelated species of plant, animal, or microbe containing the 
characteristics they want to transfer to the plant host. They use polymerase 
chain reaction to copy the gene along with promoter and terminator genes 
(which up- and downregulate the gene of interest) and marker genes (which 
signal successful genetic modification). This packet is transferred to the 
host plant by various means, including bacterial vectors that can penetrate 
cells and introduce the recombinant DNA into the host plant's genome.[9]

"The reason I don't worry about GMOs is not because someone has convinced me 
with a big study that they're safe," says Michael Eisen, an associate 
professor of genetics, genomics, and development at the University of 
California, Berkeley, and an investigator at the Howard Hughes Medical 
Institute. "It's because when I look at the technology, I understand what 
this technology is doing. They're introducing proteins that have been very 
well characterized into plants, and I don't see any reason at all to suspect 
that these are harmful." He adds, "That's a point that people don't seem to 
get: High-fructose corn syrup derived from corn that has a bacterial toxin 
in it to kill insects is no different from high-fructose corn syrup derived 
from conventional corn. It's literally molecularly identical."

As for actual health effects, Lemaux says of her two-part review of the 
literature related to GE food safety,[10,11] "I haven't found any evidence 
of anything on the commercial market now causing any more health problems 
than things that are conventionally produced or organically produced."

A review of studies on animals fed GE plant diets also found no evidence of 
health hazards.[12] The authors examined 24 studies, half of them 
multigenerational, of animals fed diets of GE maize, potatoes, soybeans, 
rice, or triticale (a wheat–rye hybrid). They concluded, "The studies 
reviewed present evidence to show that [GE] plants are nutritionally 
equivalent to their non-[GE] counterparts and can be safely used in food and 
feed."

And in May 2012 the EU's food safety body, the European Food Safety 
Authority, rejected an attempt by France to ban the planting of MON 810, an 
insect-resistant strain of GE maize developed by Monsanto, because there is 
"no specific scientific evidence, in terms of risk to human and animal 
health or the environment" to justify a ban.[13]

Red Flags
Some scientists, however, believe questions about the safety of GE foods are 
far from answered. Doug Gurian-Sherman, senior scientist with the Food and 
Environment Program at the Union of Concerned Scientists, says the question 
is not whether there's risk involved GE foods, but whether it's greater than 
risks posed by conventional foods. "Because of the greater capacity to bring 
unknown quantities into the food supply, I'm of the school that says it has 
somewhat higher potential for risk," he says. "Other scientists say no. But 
I don't think it's a settled debate."

Hansen responds to claims that there's no evidence of harm from GE foods by 
saying, "That's just not true. I can show you all kinds of studies in the 
scientific literature that have … raised red flags that need to be followed 
up on." In one such study, investigators reviewed 19 studies of mammals fed 
GE soybeans and maize. They found that "several convergent data appear to 
indicate liver and kidney problems as end points of GMO diet effects," with 
the kidneys more affected in males and the liver more affected in 
females.[14] The authors, noting the limitations of the 28- and 90-day 
assays they reviewed, pointed out that chronic toxicity testing is not 
required for GE foods, but that it should be.

Another study involved 30 pregnant and 39 nonpregnant women in Quebec and 
their exposure to pesticides associated with GE foods, including Cry1Ab, an 
insecticidal toxin produced by Bacillus thuringiensis (Bt) that is 
introduced to some GE crops to confer pest resistance.[15] The researchers 
detected Cry1Ab in 93% of pregnant women tested, 80% of their fetuses, and 
69% of nonpregnant women tested. Citing other studies that found trace 
amounts of Cry1Ab in the gastrointestinal contents of livestock fed GE corn, 
the authors suggest the toxin may not be effectively eliminated in 
humans—potentially a concern for the vulnerable fetus—and that eating 
contaminated meat may pose a risk of exposure. The human health effects of 
Cry1Ab exposure are unknown.

Meanwhile, Hansen also believes there's evidence to suggest a connection 
between GE crops and allergenicity, which he says is good enough reason to 
label foods for GMOs. He points to data from the Centers for Disease Control 
and Prevention showing an 18% increase in reported food allergy cases among 
children between 1997 and 2007.[16] "Is there any connection [with the 
concurrent increase in GE crop production]?" he asks. "You don't know, 
because if there's no labeling or any other way to tell, how would you 
know?"

In response to the argument that nobody's getting sick from these crops, 
Gurian-Sherman says, "That's just scientifically unsupportable. I'm not 
suggesting people are getting sick, but there's no data to support that. 
Outside of acute toxicity, you can't know that without doing epidemiology. 
That's why we do epidemiology about saturated fats and trans fats and 
chemicals in our food—because it's not obvious."

Premarket Testing
The American Medical Association (AMA) House of Delegates recently 
considered a proposal to endorse the labeling of GE foods but ultimately 
rejected it, stating that "as of June 2012, there is no scientific 
justification for special labeling of bioengineered foods, as a class, and 
that voluntary labeling is without value unless it is accompanied by focused 
consumer education." The AMA instead adopted a policy statement urging 
"government, industry, consumer advocacy groups, and the scientific and 
medical communities to educate the public and improve the availability of 
unbiased information and research activities on bioengineered foods."[17]

The AMA also took a position in favor of mandatory premarket safety testing 
of all GE foods. In a statement to the Los Angeles Times following the 
action, AMA Board of Trustees member Patrice Harris said, "Recognizing the 
public's interest in the safety of bioengineered foods, the new policy also 
supports mandatory FDA [Food and Drug Administration] premarket systemic 
safety assessments of these foods as a preventive measure to ensure the 
health of the public. We also urge the FDA to remain alert to new data on 
the health consequences of bioengineered foods."[18] Hansen calls this 
support for mandatory premarket safety assessments "huge."

Under the 1992 policy that regulates GE foods in the United States, the FDA 
essentially considers these foods no different than conventional foods, and 
premarket testing is voluntary.[19] The result, critics charge, is a 
complete lack of transparency around the science that companies have 
conducted on their GE products. "There hasn't been much independent science 
done or much review of the science," Malkan says.

By the same token, says FDA spokesman Curtis Allen, "[GE foods] must meet 
the same legal standards, including safety standards, as foods derived from 
their non-GE counterparts." Allen says firms may voluntarily indicate 
through labeling whether foods have or have not been developed through 
genetic engineering, and the policy also established a voluntary process 
through which producers might consult with the FDA about safety and 
regulatory issues before marketing the product.[20]

Gregory Jaffe, director of the Biotechnology Project at the Center for 
Science in the Public Interest in Washington, DC, says his organization has 
been pushing for mandatory premarket approval of GE foods for a long time, 
but not for labeling. "We think if there's any question about the safety of 
these foods, they should not be allowed to be eaten," he says. "They should 
not be allowed to be put on the market. But labeling shouldn't be a 
surrogate for safety. So our view would be: If there's any question of 
safety, don't allow it in the food supply. We want to leave mandatory 
labeling to things that are directly related to the health and safety of 
existing food."

Weed Resistance
Although Lemaux believes GE foods themselves are safe, she does think 
there's another aspect of GE production that warrants more serious 
attention: the environmental effects. "I think we most definitely need to be 
concerned about overuse of herbicides and overuse of Bt crops," she says. 
"We've learned that before with other agricultural technologies—that if you 
overuse them, you get in trouble, and we're seeing those signs now."

Lemaux is referring to growing evidence that nature has been catching up to 
the ability of GE crops to defy weeds. For years, many farmers have been 
relying on a single tactic to manage weeds: post-emergence applications of 
the herbicide glyphosate to "Roundup Ready" crops that have been 
bioengineered to withstand the weedkiller. This approach has allowed farmers 
to engage in no-till agriculture, which involves minimal disturbance of the 
soil and thus reduces labor time as well as chemical runoff.[21]

But in the second decade of the GE commercialization experiment, 
investigators are reaching seemingly contradictory conclusions as to whether 
these crops actually reduce herbicide use over time.[21,22] And in the last 
couple of years there have been numerous reports of the emergence of 
"superweeds" that are immune to glyphosate, forcing farmers to resort to 
harsher chemical measures, such as 2,4-D, an herbicide used in the defoliant 
Agent Orange.

Dow AgroScience has applied to the U.S. Department of Agriculture for 
approval to sell a new GE corn seed that is resistant to 2,4-D,[23] and a 
decision is expected by fall 2012. The agency has received many comments 
criticizing Dow's request, including one signed by a long list of farm, 
food, health, public interest, consumer, fishery, and environmental 
organizations who see only more herbicide resistance in the offing.[24] 
"Farmers would have no interest in 2,4-D[-resistant] crops if there weren't 
a raging epidemic of weeds resistant to glyphosate," the group wrote. "Weed 
resistance to 2,4-D will not be prevented or even slowed by the approaches 
that failed so spectacularly with Roundup Ready crops: voluntary 
'stewardship' plans and grower education."

Meanwhile, back in California, where the GE debate is focused on the 
opposite end of the food-production pipeline, both sides are engaged in a 
pitched battle to win voters between now and Election Day. But whether the 
California initiative passes or not, it appears that questions about GE 
foods won't be going away any day soon.

"You can never prove, in any scientifically verifiable way, that GE foods 
are 'safe'—you can only verify whenthey are unsafe," says Frederick L. 
Kirschenmann, distinguished fellow at the Leopold Center for Sustainable 
Agriculture at Iowa State University. "None of this means that GE foods are 
not safe. It just means that we do not know, because we do not know if we 
have thought of all the possible aspects of the innovation that might be 
unsafe to eat. That, from my perspective, is the strongest argument I know 
of for labeling—so that individuals can choose for themselves whether to eat 
it or not."

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